[34] D. LaBarre and R. Lowy, “Improvements in methods for calculating virus titer

estimates from TCID50 and plaque assays,” J. Virol. Methods, vol. 96, no. 2,

pp. 107–126, 2001.

[35] A. Roldão, R. Oliveira, M. Carrondo, and P. Alves, “Error assessment in re-

combinant baculovirus titration: evaluation of different methods,” J. Virol. Methods,

vol. 159, no. 1, pp. 69–80, Jul. 2009.

[36] I. V. Gates, Y. Zhang, C. Shambaugh, M. A. Bauman, C. Tan, and J. L. Bodmer,

“Quantitative measurement of varicella-zoster virus infection by semiautomated flow

cytometry,” Appl. Environ. Microbiol., vol. 75, no. 7, pp. 2027–2036, Apr. 2009.

[37] B. Grigorov, J. Rabilloud, P. Lawrence, and D. Gerlier, “Rapid titration of measles

and other viruses: optimization with determination of replication cycle length,”

PLoS One, vol. 6, no. 9, p. e24135, 2011.

[38] R. Gustafsson, E. Engdahl, and A. Fogdell-Hahn, “Development and validation of a

Q-PCR based TCID50 method for human herpesvirus 6,” Virol. J., vol. 9, 311,

2012. https://doi.org/10.1186/1743-422X-9-311

[39] A. Calderaro, M. Arcangeletti, I. Rodighiero et al., “Identification of different

respiratory viruses, after a cell culture step, by matrix assisted laser desorption/

ionization time of flight mass spectrometry (MALDI-TOF MS),” Sci. Rep., vol. 6,

36082, Oct. 2016.

[40] T. Santiago-Rodriguez, “Identification and quantification of DNA viral populations

in human urine using next-generation sequencing approaches,” Methods Mol. Biol.,

vol. 1838, pp. 191–200, 2018.

[41] K. Toohey-Kurth, S. Sibley, and T. Goldberg, “Metagenomic assessment of ad-

ventitious viruses in commercial bovine sera,” Biologicals, vol. 47, pp. 64–68, May

2017.

[42] A. Brussel et al., “Use of a new RNA next generation sequencing approach for the

specific detection of virus infection in cells,” Biologicals, vol. 59, pp. 29–36, May

2019.

[43] J. Cheval, E. Muth, G. Gonzalez , M. Coulpier, P. Beurdeley, S. Cruveiller,

and M. Eloit, “Adventitious virus detection in cells by high-throughput sequencing

of newly synthesized RNAs: unambiguous differentiation of cell infection from

carryover of viral nucleic acids,” mSphere, vol. 4, no. 3, e00298‐19, Jun. 2019.

[44] P. Duroy et al., “Characterization and mutagenesis of Chinese hamster ovary cells

endogenous retroviruses to inactivate viral particle release,” Biotechnol. Bioeng.,

vol. 117, no. 2, pp. 466–485, Feb. 2020.

[45] J. Mascarenhas et al., “Genetic engineering of CHO cells for viral resistance to

minute virus of mice,” Biotechnol. Bioeng., vol. 114, no. 3, pp. 576–588, Mar. 2017.

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